The scope of the journal encompasses neurophysiological mechanisms underlying sensory, motor, and cognitive functions in health and disease. We suggest that both task-driven neuronal responses and behavior are reflections of this dynamic, ongoing, functional organization of the brain. Founded in 1966, Experimental Brain Research publishes original contributions on many aspects of experimental research of the central and peripheral nervous system. This intrinsic organization, featuring the presence of anticorrelated networks in the absence of overt task performance, provides a critical context in which to understand brain function. ![]() ![]() We are supported by a generous grant from the Nomis Foundation. One network consists of regions routinely exhibiting task-related activations and the other of regions routinely exhibiting task-related deactivations. The Noonan Lab in the Department of Genetics, Yale School of Medicine, is recruiting postdoctoral fellows to join a major collaborative project to study the evolution of the human brain. We identify two diametrically opposed, widely distributed brain networks on the basis of both spontaneous correlations within each network and anticorrelations between networks. In this study, we investigate the extent to which this task-related dichotomy is represented intrinsically in the resting human brain through examination of spontaneous fluctuations in the functional MRI blood oxygen level-dependent signal. ![]() ![]() During performance of attention-demanding cognitive tasks, certain regions of the brain routinely increase activity, whereas others routinely decrease activity.
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